• Understanding biological complexity, from genotype to phenotype, with interdisciplinary approaches.
  • Understanding biological complexity, from genotype to phenotype, with interdisciplinary approaches.
  • Understanding biological complexity, from genotype to phenotype, with interdisciplinary approaches.

Bioinformatics and genomics of molecular networks

This research axis aims at deciphering the functional organization of the genome, defining the functional role of non coding transcripts, analyzing the molecular interactions at the DNA, RNA or protein level, developing new strategies to integrate heterogeneous information.

 

Genetics and genomics of multifactorial diseases

This research axis aims at identifying genes and mechanisms underlying the complex phenotypes in multifactorial diseases such as haematological malignancies, sepsis, malaria, and cardiomyopathies.

Education

TAGC Members are actively involved in education and propose various theoretical and practical courses related to molecular biology, genetics, genomics, bioinformatics, statistics and informatics.

Attendees range from BSc, MSc, and PhD students to postdoctoral fellows and researchers.

Next Generation Sequencing Facility - TGML

The Transcriptomic and Genomic Marseille-Luminy (TGML) platform is involved in transcriptomic and genomic data production and analysis since 2001.

Bioinformatics Core Facility Calanques - BCF-C

The Bioinformatic Core Facility offers bioinformatic support on data analysis and software development.

Bioinformatics Resources and Biological Platforms

The TAGC members develop and deploy bioinformatics tools, databases and workflows ranging from next generations sequencing data analysis to network analysis.

The TAGC also own platforms for molecular biology, cell culture imaging and animals breeding.

Our goal

Understanding biological complexity, from genotype to phenotype, with interdisciplinary approaches.

Events

16 Nov 2018

Internal Seminar - Saadat Hussain

20 Nov 2018

EXTERNAL SEMINAR - Daniel Rico : Network approaches to understand chromatin interactions and gene regulation

Seminar of Daniel Rico from the Institute of Cellular Medicine, Newcastle University (UK).

Title: Network approaches to understand chromatin interactions and gene regulation

Place: Campus of Luminy. Seminar room TPR2, Bloc 5. November 20th @ 11h00

Summary

Our research focuses in understanding how to read the genome so we can identify the instructions for building different cell types. We develop and apply new computational methods to integrate genomic, epigenomic and transcriptomic data to decode these instructions. We collaborate with colleagues at Newcastle University and the Great North Children Hospital to understand which mutations can cause “typos” in these instructions, leading to diseases. We are particularly interested in the immune system, where we are investigating how chromatin contributes to sex-specific immune responses. In addition, we have exciting collaborations where we are trying to understand the functional role of chromatin dynamics during mitosis and the interplay of chromatin and genomic translocations in leukemias.

Websitehttps://www.ncl.ac.uk/icm/people/profile/danielrico

Selected publications

* Rigau M, Juan D, Valencia A, Rico D. Widespread population variability of intron size in evolutionary old genes: implications for gene expression variability. BioRxiv 2017, Epub ahead of print.

* Pancaldi V, Carrillo-de-Santa-Pau E, Javierre BM, Juan D, Fraser P, Valencia A, Rico D. Integrating epigenomic data and 3D genomic structure with a new measure of chromatin assortativity. Genome Biology 2016, 17, 152.

* Carrillo-de-Santa-Pau E, Juan D, Pancaldi V, Were F, Martin-Subero I, Rico D, Valencia A, The BLUEPRINT Consortium. Automatic identification of informative regions with epigenomic changes associated to hematopoiesis. Nucleic Acids Research 2017, 45(16), 9244-9259.

News

  1. PhD Thesis defense - Mustafa Abuelqumsan

     

    Assessment of Supervised Classification Methods for the Analysis of RNA-seq Data

    December 20th, 2018

  2. PhD Thesis defense - Michel Sanka

     

    Comprehension des mécanismes moléculaires et des facteurs génétiques impliqués dans le paludisme sévère : analyse des profils transciptomiques et processus biologiques caractéristiques du neuropaludisme et meta-analyse sur des genes associés à la résistance au paludisme.

    Mercredi 19 décembre - 14h Amphithéatre 12, Batiment B

  3. Phd Thesis defense - Diogo Ribeiro

     

    Discovery of the role of protein-RNA interactions in protein multifunctionality and cellular complexity

    December 5th, 2018 - 14h, MIO amphitheater.

  4. ANR project Epromoters
  5. MoonDB v2 is live and cross-referenced by Uniprot

    MoonDB, the Database of Extreme Multifunctional and Moonlighting Proteins built in the TAGC (Nature Communications 6, 7412 (2015)) is now in its second version, with an updated content, and is cross-referenced by Uniprot.

     

  6. Image of the "Ligue contre le cancer"
    Label "Ligue Contre Le Cancer"

Latest publications