• Understanding biological complexity, from genotype to phenotype, with interdisciplinary approaches.
  • Understanding biological complexity, from genotype to phenotype, with interdisciplinary approaches.
  • Understanding biological complexity, from genotype to phenotype, with interdisciplinary approaches.

Bioinformatics and genomics of molecular networks

This research axis aims at deciphering the functional organization of the genome, defining the functional role of non coding transcripts, analyzing the molecular interactions at the DNA, RNA or protein level, developing new strategies to integrate heterogeneous information.


Genetics and genomics of multifactorial diseases

This research axis aims at identifying genes and mechanisms underlying the complex phenotypes in multifactorial diseases such as haematological malignancies, sepsis, malaria, and cardiomyopathies.


TAGC Members are actively involved in education and propose various theoretical and practical courses related to molecular biology, genetics, genomics, bioinformatics, statistics and informatics.

Attendees range from BSc, MSc, and PhD students to postdoctoral fellows and researchers.

Next Generation Sequencing Facility - TGML

The Transcriptomic and Genomic Marseille-Luminy (TGML) platform is involved in transcriptomic and genomic data production and analysis since 2001.

Bioinformatics Core Facility Calanques - BCF-C

The Bioinformatic Core Facility offers bioinformatic support on data analysis and software development.

Bioinformatics Resources and Biological Platforms

The TAGC members develop and deploy bioinformatics tools, databases and workflows ranging from next generations sequencing data analysis to network analysis.

The TAGC also own platforms for molecular biology, cell culture imaging and animals breeding.

Our goal

Understanding biological complexity, from genotype to phenotype, with interdisciplinary approaches.


26 Mar 2019

EXTERNAL SEMINAR - Antoine Claessens, DIMNP - UMR 5235 Université de Montpellier

Titre :  Le silence assourdissant du portage asymptomatique du Plasmodium falciparum

Title: Plasmodium falciparum asymptomatic infections: in search of the elephant in the room

29 Mar 2019

Internal Seminar - José David Abad Flores


  1. New funding - A*Midex International

    Christophe Chevillard was one of the Laureat of the A*Midex International grant with the project MITOMUTCHAGAS.

    Subject: Additive effect of pathogenic mutations in mitochondrial proteins and inflammatory cytokines in mitochondrial dysfunction and innate immunity: relevance for Chagas disease cardiomyopathy

    Thematic axis: Heath and life science

  2. Chromatin Meets South - Marseille, July 01-02, 2019

    This 2-day informal meeting is the 9th edition in the conference series «Chromatin Meets South». It is focused on fundamental aspects of chromatin biology and on the latest advances in understanding chromatin structure and function, gene expression and genome integrity. This meeting will bring together leading researchers from the South of France to explore outstanding questions in chromatin-related topics and enable participants to identify new research opportunities and collaborations, and to allow PhD students and post-doc fellows to present their results to a large audience.

  3. New equipment : flow cytometer analyzer and cell sorter

    The institute has just obtained 150 k€ from the PACA Region to equip the cell culture platform of the INSERM-TPR2 building on state of the art flow cytometer analyzer and cell sorter. The application was led by Salvatore Spicuglia along with other researcher from the U1097, U1067, U1072 Inserm units. These equipments will provide new opportunities for the TPR2 units and a large number of regional actors to develop new techniques for functional analysis and sorting of rare cell populations from valuable and/or infected samples.

  4. ENHPATHY, a multidisciplinary consortium
  5. TAGC, winner of the transversal program "GENOMIC VARIABILITY 2018"

    The objective of the transversal programme "Genomic Variability 2018" is to understand the role played by genes and their variants on the development of pathologies by using both longitudinal monitoring of individual cohorts and their phenotyping and by promoting the development of new methods for the analysis of longitudinal data.  This knowledge base will contribute to improving the interpretation of the association between genetic variants detected in an individual and a disease or endophenotype and to better understand the role played by genes in phenotypic variability.

  6. The Bettencourt Schueller Foundation honours Salvatore Spicuglia

    On December 10, 2018, the Bettencourt Schueller Foundation awarded its annual scientific prizes to 19 researchers whose work contributes to the advancement of scientific knowledge on major health and environmental issues. The total allocation of these prizes amounts to nearly €2 million. For the first time, the awards ceremony took place in the André and Liliane Bettencourt auditorium of the Institut de France, in the presence of Françoise Bettencourt Meyers, President of the Bettencourt Schueller Foundation, Xavier Darcos, Chancellor of the Institut de France and Hugues de Thé, President of the Scientific Council of the Bettencourt Schueller Foundation.

  7. ANR project Epromoters
  8. MoonDB v2 is live and cross-referenced by Uniprot

    MoonDB, the Database of Extreme Multifunctional and Moonlighting Proteins built in the TAGC (Nature Communications 6, 7412 (2015)) is now in its second version (Nucl. Acids Res. 47 (D1), D398-D402 (2019)), with an updated content, and is cross-referenced by Uniprot.


Latest publications