1. BIOINFORMATICS AND GENOMICS OF MOLECULAR NETWORKS

Les activités de recherche de l'axe 1 se concentrent sur deux domaines principaux :

Génomes. Comprendre comment la régulation précise de l'expression des gènes au cours du développement normal et de la différenciation cellulaire est obtenue par l'action combinée de différents éléments régulateurs.

Réseaux. Analyser les réseaux d'interaction pour comprendre l'émergence des phénotypes, élucider les mécanismes moléculaires sous-jacents et étudier l'effet des perturbations sur la topologie des réseaux et les fonctions cellulaires.

Thèmes de recherche actuels :

1.1  Bioinformatics of Regulatory Sequences (4)
1.2  Discovery and functional dissection of Regulatory Elements (5) 
1.3  Bioinformatics of gene regulation underlying phenotypic traits (4) 
1.4  Network bioinformatics of cellular functions and phenotypes (3)

 

2. GENETICS AND GENOMICS OF MULTIFACTORIAL DISEASES

Les activités de recherche de l'axe 2 visent à identifier les gènes et les mécanismes qui sous-tendent des phénotypes complexes, tels que le vieillissement et les maladies multifactorielles, avec un accent particulier sur les maladies infectieuses et inflammatoires (malaria, maladie de Chagas, cardiomyopathies, septicémie) et les hémopathies malignes (lymphome, leucémie) en réalisant des essais fonctionnels à haut débit et l'intégration de données multi-omiques. Un objectif à plus long terme est de proposer des stratégies de traitement personnalisé et de développer de nouvelles approches thérapeutiques.

Thèmes de recherche actuels :

2.1  Multi-omics approaches to dissect complex traits and diseases (4) 
2.2  Characterization of altered cellular functions in disease states (6) 
2.3  Physiopathology of cardiac function in model organisms (4) 
2.4  Identification of novel disease therapies (5)

A.1 - Bioinformatics and Genomics of Molecular Networks, A.1.1 - Bioinformatics of Regulatory Sequences, A.1.2 - Discovery and functional dissection of Regulatory Elements

A.1 - Bioinformatics and Genomics of Molecular Networks, A.1.4 - Network bioinformatics of cellular functions and phenotypes

A.1 - Bioinformatics and Genomics of Molecular Networks, A.1.1 - Bioinformatics of Regulatory Sequences, A.1.3 - Bioinformatics of gene regulation underlying phenotypic traits

A.1 - Bioinformatics and Genomics of Molecular Networks

A.1 - Bioinformatics and Genomics of Molecular Networks, A.1.2 - Discovery and functional dissection of Regulatory Elements, A.2 - Genetics and Genomics of Multifactioral Diseases, A.2.1 - Multi-omics approaches to dissect complex traits and diseases, A.2.2 - Characterization of altered cellular functions in disease states

A.1 - Bioinformatics and Genomics of Molecular Networks, A.2 - Genetics and Genomics of Multifactioral Diseases

A.1 - Bioinformatics and Genomics of Molecular Networks, A.1.3 - Bioinformatics of gene regulation underlying phenotypic traits, A.2 - Genetics and Genomics of Multifactioral Diseases, A.2.1 - Multi-omics approaches to dissect complex traits and diseases, A.2.2 - Characterization of altered cellular functions in disease states

A.1 - Bioinformatics and Genomics of Molecular Networks, A.1.2 - Discovery and functional dissection of Regulatory Elements, A.2 - Genetics and Genomics of Multifactioral Diseases, A.2.1 - Multi-omics approaches to dissect complex traits and diseases

A.1 - Bioinformatics and Genomics of Molecular Networks, A.1.1 - Bioinformatics of Regulatory Sequences

A.1.2 - Discovery and functional dissection of Regulatory Elements, A.2.2 - Characterization of altered cellular functions in disease states, A.2.4 - Identification of novel disease therapies

A.1.2 - Discovery and functional dissection of Regulatory Elements, A.2 - Genetics and Genomics of Multifactioral Diseases

A.1.4 - Network bioinformatics of cellular functions and phenotypes, A.2.2 - Characterization of altered cellular functions in disease states, A.2.4 - Identification of novel disease therapies

A.2 - Genetics and Genomics of Multifactioral Diseases, A.2.3 - Physiopathology of cardiac function in model organisms

A.2 - Genetics and Genomics of Multifactioral Diseases, A.2.1 - Multi-omics approaches to dissect complex traits and diseases, A.2.2 - Characterization of altered cellular functions in disease states, A.2.3 - Physiopathology of cardiac function in model organisms, A.2.4 - Identification of novel disease therapies