On November 29th, we will have an external seminar by Dr. Cyril Esnault. He is an Inserm researcher at the Genomic and Molecular Institute of Montpelier (IGMM). His work focuses on the role of Mechanical stress in regulating gene expression.  Note that his talk will precede Juliette’s defense the same day.

Friday, November 29th, 2024,11h00, Conference room building TPR2, bloc 5

            Dr. Cyril Esnault, IGMM, Montpellier

Mechanical cues shape the nuclear organization and gene expression programs

Key publications:

Esnault C, Magat T, Zine El Aabidine A, Garcia-Oliver E, Cucchiarini A, Bouchouika S, Lleres D, Goerke L, Luo Y, Verga D, Lacroix L, Feil R, Spicuglia S, Mergny JL, Andrau JC.G4access identifies G-quadruplexes and their associations with open chromatin and imprinting control regions. Nat Genet. 2023 Aug;55(8):1359-1369. doi: 10.1038/s41588-023-01437-4. Epub 2023 Jul 3.PMID:37400615.

Esnault C, Magat T, García-Oliver E, Andrau JC. Analyses of Promoter, Enhancer, and Nucleosome Organization in Mammalian Cells by MNase-Seq. Methods Mol Biol. 2021;2351:93-104. doi: 10.1007/978-1-0716-1597-3_5. PMID:34382185.

Esnault C, Gualdrini F, Horswell S, Kelly G, Stewart A, East P, Matthews N, Treisman R. ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chromatin Modification Cascade Associated with Transcription. Mol Cell. 2017 Mar 16;65(6):1081-1095.e5. doi: 10.1016/j.molcel.2017.02.005. Epub 2017 Mar 9.PMID: 28286024; PMCID: PMC5364370.

Gualdrini F*, Esnault C*, Horswell S, Stewart A, Matthews N, Treisman R. SRF Co-factors Control the Balance between Cell Proliferation and Contractility. Mol Cell. 2016 Dec 15;64(6):1048-1061. doi: 10.1016/j.molcel.2016.10.016. Epub 2016

Nov 17. PMID: 27867007; PMCID: PMC5179500.