Bioinformatics and genomics of molecular networks
This research axis aims at deciphering the functional organization of the genome, defining the functional role of non coding transcripts, analyzing the molecular interactions at the DNA, RNA or protein level, developing new strategies to integrate heterogeneous information.
Genetics and genomics of multifactorial diseases
This research axis aims at identifying genes and mechanisms underlying the complex phenotypes in multifactorial diseases such as haematological malignancies, sepsis, malaria, and cardiomyopathies.
Education
TAGC Members are actively involved in education and propose various theoretical and practical courses related to molecular biology, genetics, genomics, bioinformatics, statistics and informatics.
Attendees range from BSc, MSc, and PhD students to postdoctoral fellows and researchers.
Next Generation Sequencing Facility - TGML
The Transcriptomic and Genomic Marseille-Luminy (TGML) platform is involved in transcriptomic and genomic data production and analysis since 2001.
TAGC is part of Centuri
The Turing Centre for Living Systems (CENTURI) is an interdisciplinary project located in Marseille (France). CENTURI aims at developing an integrated interdisciplinary community, to decipher the complexity of biological systems through the understanding of how biological function emerges from the organization and dynamics of living systems.
Bioinformatics Resources and Biological Platforms
The TAGC members develop and deploy bioinformatics tools, databases and workflows ranging from next generations sequencing data analysis to network analysis.
The TAGC also own platforms for molecular biology, cell culture imaging and animals breeding.
Our goal
Understanding biological complexity, from genotype to phenotype, with interdisciplinary approaches.
Events
24 May 2024
Internal seminar - M2 students
News
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SOUTENANCE DE THÈSE - PHD DEFENSE – LAMIA MADACILECEMIES AIGUE: MECANISMES DE RESISTANCE AU TRAITEMENT
Thursday, May 23, 2024 at 1pm
Auditorium - Amphi 4 - Bat A - 172 Av. de Luminy, 13009 Marseille
Composition du jury:
M. Régis COSTELLO - Directeur de thèse
M. Pascal RIHET - Co-directeur de thèse
M. Vahid ASNAFI - Rapporteur
M. Jean-Paul FEUGEAS - Rapporteur
Mme Véronique BACCINI - Examinatrice
Mme Mireille VERDIER-SAGE - Examinatrice
Mme Marie LOOSVELD - PrésidenteRésumé
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meeting “CRISPR Screening in Cancer Discovery”CRISPR’it Core Facility and CRISPR Screen Action (from PACA region) co-organize the second edition of the meeting “CRISPR Screening in Cancer Discovery”
This event will take place at Institut Curie in Paris on Tuesday 24th of September 2024.
The meeting will bring together international leaders in the field who will present their latest findings on the use of these approaches in the discovery of new therapeutic avenues including immunotherapies, understanding the epigenetic mechanisms underlying tumor growth or the state of art of innovative screening approaches in 3D tumor models (eg organoids, in vivo, etc.).
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SOUTENANCE DE THÈSE - PHD DEFENSE – JING WANCOMPREHENSIVE MAPPING OF HUMAN GENETIC VARIATION AT EPROMOTERS
"Cartographie des variations génétiques humaines dans les Epromoters"
Friday, June 21th at 9:00 am
Auditorium - Hexagone 172 Av. de Luminy, 13009 MarseilleComposition of jury
Denis PUTHIER, President of jury - Aix-Marseille University, Marseille, France
Mikhail SPIVAKOV, Reporter - Imperial College, London, UK
Anaïs FLORE BARDET, Reporter - University of Strasbourg, Illkirch, France
Salvatore SPICUGLIA, Supervisor - TAGC-Inserm, Marseille, France
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festival « EXPLORE, à la rencontre de la recherche »« Du 27 mai au 2 juin 2024, le festival EXPLORE s’installe à Marseille pour sa première édition. Co-organisé par Aix-Marseille Université et le CNRS en partenariat avec Centrale Méditerranée et l’Inserm, c’est un nouveau rendez-vous festif, gratuit et ouvert à toutes et tous, petits et grands. Plus de 80 scientifiques viennent à la rencontre des Marseillaises et Marseillais à travers des activités ludiques et interactives. L’occasion de plonger au coeur de la recherche et d'explorer son impact sur notre quotidien ! Au programme : tête-à-tête insolites, immersion virtuelle, visites de laboratoires et bien plus encore.
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Transition @TAGCLe TAGC a adopté une charte et s'engage pour le climat.
Voici la charte rédigée par le groupe de travail transition et validée par les membres du laboratoire en Assemblée Générale.
Charte environnementale du TAGC
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Post-doc A*MIDEX pour Pauline ANDRIEUXNous avons eu la réponse d'A*MIDEX.
Pauline ANDRIEUX vient d'obtenir officiellement son post doc de trois ans.
Félicitations à Pauline qui a travaillé dur pour l'obtenir depuis des années, après une excellente thèse (https://hal.science/tel-04408896) sous la direction de Christophe Chevillard.
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CHROMATIN MEETS SOUTH 10th anniversaryMarseille, June 13-14, 2024
We are very pleased to announce the opening of the registration for the 10th anniversary of the conference series «Chromatin Meets South».
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SOUTENANCE DE THÈSE - PHD DEFENSE – PIERRE DE LANGENCARTOGRAPHIE ET SIGNIFICATION BIOLOGIQUE DES REGIONS INTERGENIQUES TRANSCRITES DU GENOME HUMAIN
" Mapping and Biological Significance of the Transcribed Intergenic Regions of the Human Genome"
Monday, March 18th at 9:00 am
Auditorium - Hexagone 172 Av. de Luminy, 13009 MarseilleJury :
Sarah DJEBALI - Rapportrice
Charles LECELLIER - Rapporteur
Andrée DELAHAYE-DURIEZ - Examinatrice
Salvatore SPICUGLIA - Président du jury
Benoît BALLESTER - Directeur de thèse
Lionel SPINELLI - Membre invité
Pages
Latest publications
http://api.archives-ouvertes.fr/search/TAGC?&rows=5&fl=title_s,en_title_s,docid,label_s,en_label_s,docType_s,authIdHal_s,halId_s,structId_i,uri_s,keyword_s,en_keyword_s,authLastNameFirstName_s,journalTitle_s,abstract_s,en_abstract_s,producedDate_tdate,producedDateY_i,language_s,fileMain_s&sort=publicationDate_s+desc
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From Genome-wide Association Studies to Functional Variants: ARL14 Cis - regulatory Variants Are Associated With Severe MalariaJournal of Infectious Diseases2024
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Atlas and biological significance of transcribed intergenic regions of the human genome2024
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The pathogen-encoded signalling receptor Tir exploits host-like intrinsic disorder for infectionCommunications Biology2024
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Single-Cell Transcriptome Analysis of Acute Myeloid Leukemia Cells Using Methanol Fixation and CryopreservationDiseases2023
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Parasite DNA and Markers of Decreased Immune Activation Associate Prospectively with Cardiac Functional Decline over 10 Years among Trypanosoma cruzi Seropositive Individuals in BrazilInternational Journal of Molecular Sciences2023
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