1. BIOINFORMATICS AND GENOMICS OF MOLECULAR NETWORKS

The research activities in Axis 1 are focused on two main areas:

  1. Genomes. Understand how the precise regulation of gene expression during normal development and cell differentiation is achieved by the combined action of different regulatory elements.
  2. Networks. Analyze interaction networks to grasp phenotype emergence, elucidate the underlying molecular mechanisms and investigate the effect of perturbations on network topology and cellular functions.

Current research topics:

1.1  Bioinformatics of Regulatory Sequences (4)
1.2  Discovery and functional dissection of Regulatory Elements (5) 
1.3  Bioinformatics of gene regulation underlying phenotypic traits (4) 
1.4  Network bioinformatics of cellular functions and phenotypes (3)

 

2. GENETICS AND GENOMICS OF MULTIFACTORIAL DISEASES (11)

The research activities in Axis 2 aim at identifying genes and mechanisms underlying complex phenotypes, such as aging and multifactorial diseases, with a particular focus on infectious and inflammatory diseases (Malaria, Chagas disease, cardiomyopathies, sepsis) and hematological malignancies (lymphoma, leukemia) by performing high-throughput functional assays and multi-omics data integration. A more long term aim is to propose strategies for personalized treatment and development of novel therapeutic approaches.

Current research topics :

2.1  Multi-omics approaches to dissect complex traits and diseases (4) 
2.2  Characterization of altered cellular functions in disease states (6) 
2.3  Physiopathology of cardiac function in model organisms (4) 
2.4  Identification of novel disease therapies (5)

 

1.1  Bioinformatics of Regulatory Sequences

1.2  Discovery and functional dissection of Regulatory Elements

1.3  Bioinformatics of gene regulation underlying phenotypic traits 

1.4  Network bioinformatics of cellular functions and phenotypes

2. GENETICS AND GENOMICS OF MULTIFACTORIAL DISEASES

Les activités de recherche de l'axe 2 visent à identifier les gènes et les mécanismes qui sous-tendent des phénotypes complexes, tels que le vieillissement et les maladies multifactorielles, avec un accent particulier sur les maladies infectieuses et inflammatoires (malaria, maladie de Chagas, cardiomyopathies, septicémie) et les hémopathies malignes (lymphome, leucémie) en réalisant des essais fonctionnels à haut débit et l'intégration de données multi-omiques. Un objectif à plus long terme est de proposer des stratégies de traitement personnalisé et de développer de nouvelles approches thérapeutiques.

Thèmes de recherche actuels :

2.1  Multi-omics approaches to dissect complex traits and diseases

2.2  Characterization of altered cellular functions in disease states

2.3  Physiopathology of cardiac function in model organisms

2.4  Identification of novel disease therapies