• Understanding biological complexity, from genotype to phenotype, with interdisciplinary approaches.

  • Understanding biological complexity, from genotype to phenotype, with interdisciplinary approaches.

  • Understanding biological complexity, from genotype to phenotype, with interdisciplinary approaches.

Bioinformatics and genomics of molecular networks

This research axis aims at deciphering the functional organization of the genome, defining the functional role of non coding transcripts, analyzing the molecular interactions at the DNA, RNA or protein level, developing new strategies to integrate heterogeneous information.

 

Genetics and genomics of multifactorial diseases

This research axis aims at identifying genes and mechanisms underlying the complex phenotypes in multifactorial diseases such as haematological malignancies, sepsis, malaria, and cardiomyopathies.

Education

TAGC Members are actively involved in education and propose various theoretical and practical courses related to molecular biology, genetics, genomics, bioinformatics, statistics and informatics.

Attendees range from BSc, MSc, and PhD students to postdoctoral fellows and researchers.

Next Generation Sequencing Facility - TGML

The Transcriptomic and Genomic Marseille-Luminy (TGML) platform is involved in transcriptomic and genomic data production and analysis since 2001.

TAGC is part of Centuri

The Turing Centre for Living Systems (CENTURI) is an interdisciplinary project located in Marseille (France). CENTURI aims at developing an integrated interdisciplinary community, to decipher the complexity of biological systems through the understanding of how biological function emerges from the organization and dynamics of living systems.

Bioinformatics Resources and Biological Platforms

The TAGC members develop and deploy bioinformatics tools, databases and workflows ranging from next generations sequencing data analysis to network analysis.

The TAGC also own platforms for molecular biology, cell culture imaging and animals breeding.

Our goal

Understanding biological complexity, from genotype to phenotype, with interdisciplinary approaches.

Events

30 Sep 2022

External seminar - Sylvain Marcellini from the Laboratory of Development and Evolution (University of Concepcion, Chile)

Title of the seminar

Bone regeneration through osteoblastic dedifferentiation during Xenopus tropicalis skull repair

Hexagone, Campus of Luminy, September 30th @ 1 pm.

Research outline

Our laboratory studies the bone tissue from a developmental, regenerative and evolutionary perspective. In this talk, I will focus of the regeneration of the Xenopus tropicalis larval skull which is able to completely mineralize an open wound in two weeks. To understand the cellular basis of this process, we have combined high resolution imaging with a series of ATAC-seq and RNA-seq experiments. We propose that bone repair relies on osteoblastic dedifferentiation which is driven by the reactivation of the Sox2 and Oct4 stem cell genes, and by the repression of FosL1 and Fosb pro-differentiation AP-1 members.

Selected Publications

  • Leurs N, Martinand-Mari C, Debiais-Thibaud M and Marcellini S. Parallel evolution of ameloblastic SCPP genes in bony and cartilaginous vertebrates. (2022) Molecular Biology and Evolution. Vol 39 (5), pp1-11.
  • Romero A, Leurs N, Muñoz, D, Debiais-Thibaud M, Marcellini S. Divergent expression of SPARCSPARC-L and SCPP genes during jawed vertebrate cartilage mineralization. (2021) Frontiers in Genetics. Vol 12, Article 788346.
  • Debiais-Thibaud M, Simion P, Ventéo S, Muñoz, D, Marcellini S, Mazan, S, Haitina T. Skeletal mineralization in association with type X collagen expression is an ancestral feature of jawed vertebrates. (2019) Molecular Biology and Evolution. 36(10):2265-2276 PubMed.
  • Aldea D, Subirana L, Keime C, Meister L, Maeso I, Marcellini S, Gomez-Skarmeta JL, Bertrand S, and Escriva H. Genetic regulation of amphioxus somitogenesis informs the evolution of the vertebrate head mesoderm. (2019) Nature Ecology & Evolution. 3(8):1233-1240
  • Muñoz D, Castillo H, Henriquez JP, Marcellini S. Bone regeneration after traumatic skull injury in Xenopus tropicalis. (2018) Mechanisms of Development. 154(153-161)

News

  1. Les Epromoteurs contrôlent les gènes à distance
  2. The TAGC and ABD have obtained funding from the “Plan France Relance”
  3. Broad H3K4me3 domains are hijacked in leukemic cells.
  4. “…Important progress in our present knowledge of interaction networks and of the interactome are essential to understand how gene functions and regulations are integrated at the level of an organism.” Bernard Jacq (1950-2022)

    Bernard Jacq (1950-2022)

    Directeur de Recherches CNRS

    A l’international, il fut celui qui en 1999, pensa et conceptualisa l’ensemble des interactions moléculaires et génétiques d’un organisme comme un réseau qui nous informerait sur le lien entre génotype et phénotype, donnant ainsi son nom à l’interactome et au champ thématique correspondant, l’interactomique.  

  5. ReMap Regulatory Atlas becomes a native tracks in UCSC GenomeBrowser

Latest publications