Title of the seminar
“Bone regeneration through osteoblastic dedifferentiation during Xenopus tropicalis skull repair”
Hexagone, Campus of Luminy, September 30th @ 1 pm.
Our laboratory studies the bone tissue from a developmental, regenerative and evolutionary perspective. In this talk, I will focus of the regeneration of the Xenopus tropicalis larval skull which is able to completely mineralize an open wound in two weeks. To understand the cellular basis of this process, we have combined high resolution imaging with a series of ATAC-seq and RNA-seq experiments. We propose that bone repair relies on osteoblastic dedifferentiation which is driven by the reactivation of the Sox2 and Oct4 stem cell genes, and by the repression of FosL1 and Fosb pro-differentiation AP-1 members.
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