Scientific and administrative responsibilities
- Co-director of the “Cardiogenomics” research group
- Scientific leader of the “Cardiomyopathies and metabolic disorders in the Drosophila” project
- Co-responsible for communication and scientific culture
Research interests
We use the Drosophila as a model for the study of cardiac function in physiological and pathophysiological contexts.
Our projects are organized around two aspects:
- Characterizing the autonomic and systemic response of the heart to nutritional stress.
Flies fed high-sugar or high-fat diets develop cardiac dysfunctions similar to diabetic heart disease. A transcriptomic approach allows us to study the genetic basis of the heart's adaptive response to hyperglycemia and excess fat.
- Determine the natural variations in the genome associated with changes in cardiac function during aging.
Using GWAS-type association genetic analyses on a population of 200 Drosophila inbred lines (DGRP), we have identified genes encoding transcription factors that impact cardiac function during senescence.
External collaborative projects:
Functional validation of orthologs of human genes involved in Brugada syndrome (ANR funding 2022-2026)
Staff and student supervision
Student supervision :
>2024/25
Hajar Mechouat (M2 BIP, AMU, Marseille)
Darine Gadacha (M2 BIP, AMU, Marseille) , co-supervision with Christophe Chevillard (TAGC)
Jade Leroy (M1 BIP, AMU, Marseille)
<2024
Charis Aubert, Alice Corbet, Clara Rouquairol, Loïc Crespo : Master BIP, AMU, Marseille
Collaborations
Dr Sonia Stefanovic (C2VN, Marseille, France)
Dr Nuria Romero (INRAE Sophia-Antipolis, France)
Drs Flavien Charpentier, Julien Barc and Nathalie Gaborit (ANR-WIRES; Institut du Thorax, Nantes, France)
Funding
ANR-WIRES (2022-2026; Coord. Dr Flavien Charpentier, Institut du Thorax, Nantes) https://anr.fr/Projet-ANR-22-CE17-0051
External references
ORCID: https://orcid.org/0000-0001-6833-2069