In an article published in Cell Genomics, members of TAGC reveal a new DNA regulatory element, ESpromoter, with a novel dual function: it acts both as a gas pedal and a brake on two key immune system genes. This major discovery sheds light on the molecular mechanisms behind severe forms of malaria.
This work has just been published on the CNRS website:
Congratulations to all involved!
More information : Adjemout M, Nisar S, Escandell A, Torres R, Torres M, Nguyen Huu HT, Thiam A, Manosalva I, Mbengue B, Dieye A, Adoue V, Spicuglia S, Rihet P, Marquet S. Unraveling an enhancer-silencer regulatory element showing epistatic interaction with a variant that escaped genome-wide association studies. Cell Genom. 2025 May 23:100889. doi: 10.1016/j.xgen.2025.100889.