Bioinformatics and genomics of molecular networks

This research axis aims at deciphering the functional organization of the genome, defining the functional role of non coding transcripts, analyzing the molecular interactions at the DNA, RNA or protein level, developing new strategies to integrate heterogeneous information.

 

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Genetics and genomics of multifactorial diseases

This research axis aims at identifying genes and mechanisms underlying the complex phenotypes in multifactorial diseases such as haematological malignancies, sepsis, malaria, and cardiomyopathies.

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Education

TAGC Members are actively involved in education and propose various theoretical and practical courses related to molecular biology, genetics, genomics, bioinformatics, statistics and informatics.

Attendees range from BSc, MSc, and PhD students to postdoctoral fellows and researchers.

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Next Generation Sequencing Facility - TGML

The Transcriptomic and Genomic Marseille-Luminy (TGML) platform is involved in transcriptomic and genomic data production and analysis since 2001.

TAGC is part of Centuri

The Turing Centre for Living Systems (CENTURI) is an interdisciplinary project located in Marseille (France). CENTURI aims at developing an integrated interdisciplinary community, to decipher the complexity of biological systems through the understanding of how biological function emerges from the organization and dynamics of living systems.

Bioinformatics Resources and Biological Platforms

The TAGC members develop and deploy bioinformatics tools, databases and workflows ranging from next generations sequencing data analysis to network analysis.

The TAGC also own platforms for molecular biology, cell culture imaging and animals breeding.

Our goal

Understanding biological complexity, from genotype to phenotype, with interdisciplinary approaches.

Events

26 Apr 2024

Internal seminar - Thomas Steimlé

News

  1. Promotion of Bruno Pouvelle

    Fri. Dec 22 2023

    TAGC congratulates Bruno Pouvelle on his promotion to grade "Hors Classe" Research Engineer, in recognition of his involvement in research.
  2. Promotion of Frédéric Gallardo

    Mon. Dec 04 2023

    TAGC congratulates Frédéric Gallardo on his promotion to Assistant Engineer.

    This is a well-deserved reward for his work and his constant involvement in the laboratory. 
  3. Soutenance de thèse - PhD Defense - Pauline ANDRIEUX

    Tue. Dec 19 2023

    IDENTIFICATION ET CARACTERISATIONS FONCTIONNELLES DE VARIANTS GENETIQUES ASSOCIES AUX CARDIOPATHIES

    Tuesday December 19th at 1:30 pm

    Auditorium - Hexagone 172 Av. de Luminy, 13009 Marseille

    Jury :
    Mme Frédérique MAGDINIER - Présidente 
    Mme Véronique PAQUIS-FLUCKLINGER Rapportrice 
    M. Jean-Jacques SCHOTT - Rapporteur 
    Mme Alice CARRIER - Examinatrice 
    M. Vincent PROCACCIO - Examinateur 
    M. Christophe CHEVILLARD - Directeur de thèse 

     
  4. Soutenance de thèse - PhD Defense - Pauline BROCHET

    Mon. Dec 11 2023

    ETUDE DU PROCESSUS PATHOGENIQUE ASSOCIE A LA MALADIE DE CHAGAS A L'AIDE D'ANALYSES MULTI-OMIQUES

    Monday December 11th at 9:00 am

    Auditorium - Hexagone 172 Av. de Luminy, 13009 Marseille

    Jury :
    M. Philippe NAQUET - Président 
    M. Carl HERRMANN - Rapporteur 
    M. Adbellah TEBANI - Rapporteur 
    Mme Laura CANTINI - Examinateur 
    Mme Anaïs BAUDOT – invitée 
    M. Christophe CHEVILLARD - Directeur de thèse 
    M. Lionel SPINELLI - CoDirecteur de thèse 
  5. The first Chagas disease database was produced at TAGC

    Thu. Oct 12 2023

    In order to facilitate research on Chagas disease, a manual curation of all articles corresponding to “Chagas disease” referenced on PubMed has been carried out.

    Brochet, Pauline, Jean-Christophe Mouren, Laurent Hannouche, Fabrice Lopez, Benoit Ballester, Edecio Cunha-Neto, Lionel Spinelli, and Christophe Chevillard. “ChagasDB: 80 Years of Publicly Available Data on the Molecular Host Response to Trypanosoma Cruzi Infection in a Single Database.” Database 2023 (May 26, 2023): baad037. https://doi.org/10.1093/database/baad037.

  6. Groundbreaking study on intergenic transcription in both normal tissues and cancer samples, unveiling a comprehensive RNAPII atlas

    Fri. Oct 06 2023

    Pierre de Langen, Benoit Ballester et al. at TAGC have published a groundbreaking study on intergenic transcription in both normal tissues and cancer samples, unveiling a comprehensive RNAPII atlas:

    Characterizing intergenic transcription at RNA polymerase II binding sites in normal and cancer tissues

    Open Access. Published:September 29, 2023. DOI:https://doi.org/10.1016/j.xgen.2023.100411

    Summary

  7. EMBO Workshop "Enhanceropathies" in Marseille

    From Tue. Oct 17 2023 to Fri. Oct 20 2023

    After the success of the first meeting in Santander (October 2021), we are pleased to announce that registration is now open for the second edition of the EMBO Workshop "Enhanceropathies: Understanding enhancer function to understand human disease" to be held in Marseille from October 17th to 20th, 2023.

    We have an amazing speaker line-up and great opportunities for networking !

    Interested in attending? Visit the website

    Register and submit your abstract by 15 August 2023

  8. New Kids on the Block : how de novo emerged micropeptides rewire cellular networks

    Fri. Apr 28 2023

    A 3-years Human Frontier Research Grant has been obtained by Anne-Ruxandra Carvunis (Pittsburg University, USA), Erich Bornberg-Bauer (University of Münster, Germany) and Christine Brun (TAGC, France) to investigate how the products of De Novo genes evolve to adapt to the interaction network.   

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