This research axis aims at deciphering the functional organization of the genome, defining the functional role of non coding transcripts, analyzing the molecular interactions at the DNA, RNA or protein level, developing new strategies to integrate heterogeneous information.
This research axis aims at identifying genes and mechanisms underlying the complex phenotypes in multifactorial diseases such as haematological malignancies, sepsis, malaria, and cardiomyopathies.
TAGC Members are actively involved in education and propose various theoretical and practical courses related to molecular biology, genetics, genomics, bioinformatics, statistics and informatics.
Attendees range from BSc, MSc, and PhD students to postdoctoral fellows and researchers.
The Transcriptomic and Genomic Marseille-Luminy (TGML) platform is involved in transcriptomic and genomic data production and analysis since 2001.
The Turing Centre for Living Systems (CENTURI) is an interdisciplinary project located in Marseille (France). CENTURI aims at developing an integrated interdisciplinary community, to decipher the complexity of biological systems through the understanding of how biological function emerges from the organization and dynamics of living systems.
The TAGC members develop and deploy bioinformatics tools, databases and workflows ranging from next generations sequencing data analysis to network analysis.
The TAGC also own platforms for molecular biology, cell culture imaging and animals breeding.
Understanding biological complexity, from genotype to phenotype, with interdisciplinary approaches.
Title: "Computational analysis of Innate Lymphoid Cell ontogeny during embryogenesis"
Friday, November 8, 2024 at 2pm
Auditorium - CIML - 163 Av. de Luminy, 13009 Marseille
Composition du jury:
- Christine Brun (President)
- Morgane Thomas-Chollier (Reviewer)
- Christelle Harly (Reviewer)
- Rachel Golub (Examiner)
- Stéphane Mancini (Guest)
- Serge van de Pavert (Supervisor)
- Denis Puthier (Co-supervisor)
Pierre de Langen, Benoit Ballester et al. at TAGC have published a groundbreaking study on intergenic transcription in both normal tissues and cancer samples, unveiling a comprehensive RNAPII atlas:
Characterizing intergenic transcription at RNA polymerase II binding sites in normal and cancer tissues
Open Access. Published:September 29, 2023. DOI:https://doi.org/10.1016/j.xgen.2023.100411
Summary
After the success of the first meeting in Santander (October 2021), we are pleased to announce that registration is now open for the second edition of the EMBO Workshop "Enhanceropathies: Understanding enhancer function to understand human disease" to be held in Marseille from October 17th to 20th, 2023.
We have an amazing speaker line-up and great opportunities for networking !
Interested in attending? Visit the website
Register and submit your abstract by 15 August 2023
A 3-years Human Frontier Research Grant has been obtained by Anne-Ruxandra Carvunis (Pittsburg University, USA), Erich Bornberg-Bauer (University of Münster, Germany) and Christine Brun (TAGC, France) to investigate how the products of De Novo genes evolve to adapt to the interaction network.
The European network EnhPathy lead by S. Spicuglia has published a Perspective in Nature Structural & Molecular Biology highlighting about seven challenges that need to be considered in the study of enhancer dysfunction in disease.
More details here : https://rdcu.be/c1f40
L. Perrin and C. Brun groups, together with A. Colas and K. Ocorr labs at Sanford Burnham (San Diego, USA) have recently published an article:
Genetic architecture of natural variation of cardiac performance: from flies to Humans
Comprehensive Genome Wide Associations Studies in flies identify new genes and pathways critical for heart development and function and display relevant overlap with human genetic risks related to cardiac performance.
Le Journal des Sciences de France Culture présente un entretien avec Caroline Demeret, directrice de recherche à l’Institut Pasteur, responsable de l’équipe interactomique virale et autrice principale de l’article "A proteome-scale map of the SARS-CoV-2–human contactome" paru cette année dans Nature Biotechnology auquel Andreas Zanzoni et Christine Brun du TAGC ont participé.
Découvrez l'interview sur le site de Radio France.
A international consortium led by the Helmhotz Zentrum in Munich has identified more than 200 protein interactions between the virus and the human cells.
Andreas Zanzoni and Christine Brun from TAGC have contributed to the analysis of the contactome map in the context of the RiPCoN project funded by the European Union’s Horizon 2020 Research and Innovation Programme (H2020-SC1-PHE-CORONAVIRUS-2020).
Aix Marseille Université - Tous droits réservés - Mentions légales