Bioinformatics and genomics of molecular networks

This research axis aims at deciphering the functional organization of the genome, defining the functional role of non coding transcripts, analyzing the molecular interactions at the DNA, RNA or protein level, developing new strategies to integrate heterogeneous information.

 

Genetics and genomics of multifactorial diseases

This research axis aims at identifying genes and mechanisms underlying the complex phenotypes in multifactorial diseases such as haematological malignancies, sepsis, malaria, and cardiomyopathies.

Education

TAGC Members are actively involved in education and propose various theoretical and practical courses related to molecular biology, genetics, genomics, bioinformatics, statistics and informatics.

Attendees range from BSc, MSc, and PhD students to postdoctoral fellows and researchers.

Next Generation Sequencing Facility - TGML

The Transcriptomic and Genomic Marseille-Luminy (TGML) platform is involved in transcriptomic and genomic data production and analysis since 2001.

TAGC is part of Centuri

The Turing Centre for Living Systems (CENTURI) is an interdisciplinary project located in Marseille (France). CENTURI aims at developing an integrated interdisciplinary community, to decipher the complexity of biological systems through the understanding of how biological function emerges from the organization and dynamics of living systems.

Bioinformatics Resources and Biological Platforms

The TAGC members develop and deploy bioinformatics tools, databases and workflows ranging from next generations sequencing data analysis to network analysis.

The TAGC also own platforms for molecular biology, cell culture imaging and animals breeding.

Our goal

Understanding biological complexity, from genotype to phenotype, with interdisciplinary approaches.

Events

28 Jun 2024

Internal seminar - Gaelle Farah

News

  1. Current challenges in understanding the role of enhancers in disease
  2. Genetic architecture of natural variation of cardiac performance: from flies to Humans

    L. Perrin and C. Brun groups, together with A. Colas and K. Ocorr labs at Sanford Burnham (San Diego, USA) have recently published an article:

    Genetic architecture of natural variation of cardiac performance: from flies to Humans

    Comprehensive Genome Wide Associations Studies in flies identify new genes and pathways critical for heart development and function and display relevant overlap with human genetic risks related to cardiac performance.

  3. Podcast France Culture - La première cartographie des contacts moléculaires entre l'humain et le SARS-COV-2
  4. A proteome-scale map of the SARS-CoV-2 human contactome

    A international consortium led by the Helmhotz Zentrum in Munich  has identified more than 200 protein interactions between the virus and the human cells.

    Andreas Zanzoni and Christine Brun from TAGC have contributed to the analysis of the contactome map in the context of the RiPCoN project funded by the European Union’s Horizon 2020 Research and Innovation Programme (H2020-SC1-PHE-CORONAVIRUS-2020). 

     

Pages

Latest publications