Bioinformatics and genomics of molecular networks

This research axis aims at deciphering the functional organization of the genome, defining the functional role of non coding transcripts, analyzing the molecular interactions at the DNA, RNA or protein level, developing new strategies to integrate heterogeneous information.

 

Genetics and genomics of multifactorial diseases

This research axis aims at identifying genes and mechanisms underlying the complex phenotypes in multifactorial diseases such as haematological malignancies, sepsis, malaria, and cardiomyopathies.

Education

TAGC Members are actively involved in education and propose various theoretical and practical courses related to molecular biology, genetics, genomics, bioinformatics, statistics and informatics.

Attendees range from BSc, MSc, and PhD students to postdoctoral fellows and researchers.

Next Generation Sequencing Facility - TGML

The Transcriptomic and Genomic Marseille-Luminy (TGML) platform is involved in transcriptomic and genomic data production and analysis since 2001.

TAGC is part of Centuri

The Turing Centre for Living Systems (CENTURI) is an interdisciplinary project located in Marseille (France). CENTURI aims at developing an integrated interdisciplinary community, to decipher the complexity of biological systems through the understanding of how biological function emerges from the organization and dynamics of living systems.

Bioinformatics Resources and Biological Platforms

The TAGC members develop and deploy bioinformatics tools, databases and workflows ranging from next generations sequencing data analysis to network analysis.

The TAGC also own platforms for molecular biology, cell culture imaging and animals breeding.

Our goal

Understanding biological complexity, from genotype to phenotype, with interdisciplinary approaches.

Events

24 May 2024

Internal seminar - M2 students

News

  1. Soutenance de thèse - PhD Defense - Pauline BROCHET

    ETUDE DU PROCESSUS PATHOGENIQUE ASSOCIE A LA MALADIE DE CHAGAS A L'AIDE D'ANALYSES MULTI-OMIQUES

    Monday December 11th at 9:00 am

    Auditorium - Hexagone 172 Av. de Luminy, 13009 Marseille

    Jury :
    M. Philippe NAQUET - Président 
    M. Carl HERRMANN - Rapporteur 
    M. Adbellah TEBANI - Rapporteur 
    Mme Laura CANTINI - Examinateur 
    Mme Anaïs BAUDOT – invitée 
    M. Christophe CHEVILLARD - Directeur de thèse 
    M. Lionel SPINELLI - CoDirecteur de thèse 

  2. The first Chagas disease database was produced at TAGC
  3. Groundbreaking study on intergenic transcription in both normal tissues and cancer samples, unveiling a comprehensive RNAPII atlas
  4. EMBO Workshop "Enhanceropathies" in Marseille
  5. New Kids on the Block : how de novo emerged micropeptides rewire cellular networks

    A 3-years Human Frontier Research Grant has been obtained by Anne-Ruxandra Carvunis (Pittsburg University, USA), Erich Bornberg-Bauer (University of Münster, Germany) and Christine Brun (TAGC, France) to investigate how the products of De Novo genes evolve to adapt to the interaction network.   

  6. The TAGC is now on Twitter
  7. Current challenges in understanding the role of enhancers in disease
  8. Genetic architecture of natural variation of cardiac performance: from flies to Humans

    L. Perrin and C. Brun groups, together with A. Colas and K. Ocorr labs at Sanford Burnham (San Diego, USA) have recently published an article:

    Genetic architecture of natural variation of cardiac performance: from flies to Humans

    Comprehensive Genome Wide Associations Studies in flies identify new genes and pathways critical for heart development and function and display relevant overlap with human genetic risks related to cardiac performance.

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