The Transcriptomic and Genomic Marseille-Luminy (TGML) platform is involved in transcriptomic and genomic data production and analysis since 2001.
Bioinformatics and genomics of molecular networks
This research axis aims at deciphering the functional organization of the genome, defining the functional role of non coding transcripts, analyzing the molecular interactions at the DNA, RNA or protein level, developing new strategies to integrate heterogeneous information.
Genetics and genomics of multifactorial diseases
This research axis aims at identifying genes and mechanisms underlying the complex phenotypes in multifactorial diseases such as haematological malignancies, sepsis, malaria, and cardiomyopathies.
Education
TAGC Members are actively involved in education and propose various theoretical and practical courses related to molecular biology, genetics, genomics, bioinformatics, statistics and informatics.
Attendees range from BSc, MSc, and PhD students to postdoctoral fellows and researchers.
Next Generation Sequencing Facility - TGML
TAGC is part of Centuri
The Turing Centre for Living Systems (CENTURI) is an interdisciplinary project located in Marseille (France). CENTURI aims at developing an integrated interdisciplinary community, to decipher the complexity of biological systems through the understanding of how biological function emerges from the organization and dynamics of living systems.
Bioinformatics Resources and Biological Platforms
The TAGC members develop and deploy bioinformatics tools, databases and workflows ranging from next generations sequencing data analysis to network analysis.
The TAGC also own platforms for molecular biology, cell culture imaging and animals breeding.
Our goal
Understanding biological complexity, from genotype to phenotype, with interdisciplinary approaches.
News
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The TAGC is now on Twitter -
Current challenges in understanding the role of enhancers in diseaseThe European network EnhPathy lead by S. Spicuglia has published a Perspective in Nature Structural & Molecular Biology highlighting about seven challenges that need to be considered in the study of enhancer dysfunction in disease.
More details here : https://rdcu.be/c1f40
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Genetic architecture of natural variation of cardiac performance: from flies to HumansL. Perrin and C. Brun groups, together with A. Colas and K. Ocorr labs at Sanford Burnham (San Diego, USA) have recently published an article:
Genetic architecture of natural variation of cardiac performance: from flies to Humans
Comprehensive Genome Wide Associations Studies in flies identify new genes and pathways critical for heart development and function and display relevant overlap with human genetic risks related to cardiac performance.
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Podcast France Culture - La première cartographie des contacts moléculaires entre l'humain et le SARS-COV-2Le Journal des Sciences de France Culture présente un entretien avec Caroline Demeret, directrice de recherche à l’Institut Pasteur, responsable de l’équipe interactomique virale et autrice principale de l’article "A proteome-scale map of the SARS-CoV-2–human contactome" paru cette année dans Nature Biotechnology auquel Andreas Zanzoni et Christine Brun du TAGC ont participé.
Découvrez l'interview sur le site de Radio France.
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A proteome-scale map of the SARS-CoV-2 human contactomeA international consortium led by the Helmhotz Zentrum in Munich has identified more than 200 protein interactions between the virus and the human cells.
Andreas Zanzoni and Christine Brun from TAGC have contributed to the analysis of the contactome map in the context of the RiPCoN project funded by the European Union’s Horizon 2020 Research and Innovation Programme (H2020-SC1-PHE-CORONAVIRUS-2020).
Pages
Latest publications
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From Genome-wide Association Studies to Functional Variants: ARL14 Cis - regulatory Variants Are Associated With Severe MalariaJournal of Infectious Diseases2024
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Atlas and biological significance of transcribed intergenic regions of the human genome2024
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The pathogen-encoded signalling receptor Tir exploits host-like intrinsic disorder for infectionCommunications Biology2024
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Single-Cell Transcriptome Analysis of Acute Myeloid Leukemia Cells Using Methanol Fixation and CryopreservationDiseases2023
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Parasite DNA and Markers of Decreased Immune Activation Associate Prospectively with Cardiac Functional Decline over 10 Years among Trypanosoma cruzi Seropositive Individuals in BrazilInternational Journal of Molecular Sciences2023
Aix Marseille Université - Tous droits réservés - Mentions légales