Approaches combining mice and Drosophila melanogaster models to decipher human sepsis
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authors
keywords
- Oleic Acid
- Peripheral Blood Mononuclear Cell
- Reference Panel
- Sterile Inflammation
- Complex Biological Process
document type
ARTabstract
Sepsis is a complex and heterogeneous syndrome in which inflammatory and infection mechanisms are implicated. Thus, it is difficult to differentiate those mechanisms in mammals where inflammation is a highly complex biological process. In our laboratory, besides studying sepsis in human blood biological samples, we choose to investigate a murine model in ordered to describe a global transcriptome overview of critical events occurring in the blood, brain and lung during an induced non-infection inflammation. We decided to complete our view with another animal model where the inflammatory process is less complex and mainly achieved through innate immunity Drosophila melanogaster.
