Internal Seminar - Lucie Khamvongsa
Internal Seminar - Quentin Ferre
EXTERNAL SEMINAR - Christophe Lancrin, EMBL, Roma, Italy
Title: UNDERSTANDING THE FORMATION OF HEMATOPOIETIC PROGENITOR AND STEM CELLS DURING DEVELOPMENT
Place & date: Campus of Luminy. Seminar room TPR2, Bloc 5. February 11th at 13h30
The continuous generation of blood cells throughout life relies on the existence of hematopoietic stem cells (HSC) generated during embryogenesis. They have the ability to self-renew and to generate all types of blood cells. Any pathology affecting these cells could lead to development of serious diseases such as leukemia and anemia. That is why understanding how HSC and hematopoietic progenitors are produced during embryonic life is important. The cellular origin of HSC has been the subject of an intense scientific debate during the last decade. In order to better understand the development of the hematopoietic system, the focus of our research is to unravel the mechanisms underlying the generation of haemogenic endothelium and its subsequent commitment to hematopoiesis. Combining in vitro differentiation of mouse ESC with genomics, time-lapse microscopy, loss and gain of function in vitro and in vivo, we plan to identify and study the genes responsible for the generation of the first blood progenitors during embryonic life. Our aim is to gain a better understanding of the cell fate decisions leading to the production of the first hematopoietic cells and to use this knowledge to improve methods of blood cells generation from ESC or iPSC.