Insights gained from a comprehensive all- against-all transcription factor binding motif benchmarking study
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authors
keywords
- Transcription factor binding sites
- PWM
- Benchmarking
- ChIP-seq
- HT-SELEX
- PBM
document type
ARTabstract
Background: Positional weight matrix (PWM) is a de facto standard model to describe transcription factor (TF) DNA binding specificities. PWMs inferred from in vivo or in vitro data are stored in many databases and used in a plethora of biological applications. This calls for comprehensive benchmarking of public PWM models with large experimental reference sets.