Characterizing intergenic transcription at RNA polymerase II binding sites in normal and cancer tissues

authors

  • de Langen Pierre
  • Hammal Fayrouz
  • Guéret Elise
  • Mouren Jean-Christophe
  • Spinelli Lionel
  • Ballester Benoit

keywords

  • Enhancers
  • Non-coding DNA
  • Regulatory genomics
  • Intergenic
  • RNA Polymerase
  • II gene regulation
  • Cancer genomics
  • Non-coding transcription

document type

ART

abstract

Highlights d An RNAPII atlas of intergenic transcription in normal tissues and cancer samples d Intergenic atlas shows enhancer-like characteristics and transcriptional signals d Meta-clustering reveals shared transcriptional patterns among tissues and cancer types d Identified intergenic markers associated with cancer genes and survival

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