Scientific and administrative responsibilities
TAGC researcher
Member of RPS and TAGC transition cells
Research interests
Non-coding genetic variants play a key role in the regulation of genes involved in immune responses. By modulating the balance between activating and inhibiting checkpoint receptor signals, these mutations influence cytotoxic and inflammatory responses, and hence variability in the face of pathogens and tumors.
This project combines bioinformatics (PMID: 39669750) and experimental approaches (reporter assays, CRISPR-Cas9/MPRA, ADCC) to identify regulatory variants located in the FCGR cluster (encoding Fc-receptors to IgG antibodies) and in genes involved in immune escape, such as LILRB1.
We have established a link between non-coding variants regulating FCGR2B/2C and the humoral response directed against the Plasmodium falciparum parasite, associated with improved parasite control in children in malaria-endemic areas of Burkina-Faso (PMID: 37958695, 39450553).
Our project also explores regulatory variants in the expression of immune receptors, such as LILRB1 and FCGR2B, linked to the unfavorable prognosis of acute myeloid leukemia (AML) and resistance to immunotherapy treatments for B haematological malignancies.
The aim of this work is to identify genetic profiles favoring more effective humoral and cytotoxic responses, applicable to vaccination against infectious diseases and improved immunotherapies in cancer.
Teaching
Supervision of thesis and Master's students.
Staff and student supervision
current
Christelle Dieppois , PhD thesis, INSERM regional grant Oct 2023-2026
Iris Mano Salva: IR CDD AMU Amidex January 2025
Bruno Pouvelle IR TAGC
co-supervision with LAI , Post doc Ying Zhou Boursière Century
Collaborations
Ongoing collaborations
Local
Adhesion and Inflammation Laboratory (UMR7333), PI: Olivier Theodoly
Development of micro-assays with Amidex funding.
EFS-Alpes Méditerranée, PI: Christophe Picard and Pascal Pedini
Cohort analysis: study of FCGR and LIRB1 regulatory variants in relation to outcomes in lung transplantation and acute myeloid leukemia.
Alain Roussel (LISM, Marseille) and industrial partner Biocytex (Maxime Moullard)
Study of expression mechanisms of molecules targeted by nanobodies with diagnostic or prognostic value for hematological malignancies.
Pr Régis Costello (Head of Onco-Hematology Department, AP-HM/ TAGC)
Analysis of transcriptional and functional profiles associated with the prognosis of hematological malignancies (acute myeloid leukemia and circulating B lymphomas).
Collaboration with the CIC Biothérapie (Pr Sabatier and Magalon, AP-HM, Hôpital de la Conception): National PHRC project, ADICROHN II clinical trial: research assistance to identify profiles associated with the efficacy of cell therapy in Crohn's disease.
International
ISGlobal, Barcelona
Search for FCGR regulatory variants associated with anti-SARS-CoV-2 immunization.
Serge Swagadago (Joseph KI-ZERBO University, Burkina Faso, UFR/SDS)
Study of variants associated with humoral immunity in Burkinabe children.
David Courtin (IRD, Ghana)
Funding
Amidex , LAI Collaboration Olivier Theodoly 2024-2027
Canceropole Emergeance program ; fev 2025-2026
Collaboration CIC Biotherapie, AP-HM , hopital de la conception, PHRC national AP-HM clinical trial ADICROHN II coordination of biological exploration