In order to facilitate research on Chagas disease, a manual curation of all articles corresponding to “Chagas disease” referenced on PubMed has been carried out.
Brochet, Pauline, Jean-Christophe Mouren, Laurent Hannouche, Fabrice Lopez, Benoit Ballester, Edecio Cunha-Neto, Lionel Spinelli, and Christophe Chevillard. “ChagasDB: 80 Years of Publicly Available Data on the Molecular Host Response to Trypanosoma Cruzi Infection in a Single Database.” Database 2023 (May 26, 2023): baad037. https://doi.org/10.1093/database/baad037.
In total 193 articles were reviewed, dating from 1945 to 2022 and collected information on molecules present in hosts associated with T. cruzi infection.
All molecules deregulated in hosts (all mammals, human, mouse or other) following infection by T. cruzi were retrieved and included in a database, named ChagasDB.
A website has been set up to make this database accessible to all : https://chagasdb.tagc.univ-amu.fr/
